How is Water Soluble CBD even possible?

How is Water Soluble CBD even possible?

Posted by 360 Organix CBD on Aug 7th 2021

We have been told since childhood that oil and water don’t mix, so how can CBD be water-soluble? Substances like CBD and THC are highly lipophilic, meaning they dissolve in fats. Oil and water don’t mix, so how can it be water-soluble? When these two Cannabis extracts are processed, they are added to a carrier oil like MCT oil. This enables it to be absorbed and used by the body. We’ll talk a little bit about how a new technology has made it possible for CBD to be water-soluble.

These days, there is increased awareness of alternatives to pharmaceuticals for treating mental, physical, and emotional conditions. CBD is gaining popularity for therapeutic purposes. There are many known and unknown benefits, mainly because the research is still being performed. It takes years and years of research to completely know all the benefits of a particular product or substance.

Clinical trials on cannabis-based medicines have promising data for the management of pain and inflammation for a variety of physical ailments. CBD has protective and healing properties such as anti-inflammation, anticonvulsant, anxiolytic, and relief of neuropathic pain. Studies have also shown CBD to have applications for several physiological and mental conditions. The research is being done and the data is coming in to support CBD as a viable treatment for many things.

CBD Methods of Delivery

As a multi-purpose product, there are several methods of delivering CBD into your bloodstream. Many kinds of formulations containing CBD are available in the market. These formulations include edible gummies, pills, soft gel capsules, oral tinctures, topical creams, CBD oils, CBD vapes, crystals, etc.

These different formulations can be delivered through a variety of ways, such as:

  • EdiblesCapsules, Pills
  • Smoking, Vaping, Dabbing
  • Sublingual, (under the tongue)
  • Creams and Ointments
  • Each of these delivery systems has different lengths of affectability. Some are absorbed faster into the bloodstream, some last longer in the body, and some do both. The length of time CBD is available in the body will differ by application, as well as other factors pertaining to the individual user.


    Typically, CBD and other cannabinoids are hydrophobic, meaning they do not dissolve in water. To make CBD bioavailable, it needs to dissolve quickly and be able to enter the bloodstream effectively. The data we have currently says the oral bioavailability of CBD is roughly 6%. It also depends on how quickly it is metabolized by the liver.

    The liver is responsible for breaking down fats, proteins, and carbohydrates. It also breaks down medicines and distributes it to the body through the bloodstream. Unfortunately, some of the active ingredients get destroyed by the liver during the process, which is why CBD has such a low bioavailability rate. Once it is thoroughly broken down, only a small percentage of it remains to be circulated through the bloodstream.

    This doesn’t happen with topical applications of CBD. Anything that is consumed by mouth is passed to the digestive system and must go through the liver. This is why more delivery methods were necessary. People who use it can have different choices to gain maximum benefits from the product. They may choose oral CBD one day, and a topical application the next. It all comes down to individual preference.

    CBD and Nanotechnology

    Now, here is where the science of nanotechnology is making great strides. Using nano emulsion techniques, CBD-infused products can be made water-soluble. Nanoparticles are the tiniest molecules can get (x 100).

    Nano Emulsion Technology

    The exponential growth of the cannabis industry has accelerated research and development in Biotechnology. Because the Cannabis industry is growing so quickly, research in biotechnology is being done to see how to make products that have the best bioavailability, without losing any of the benefits through processing( through the liver).

    Biotech companies are inventing technology that can make agricultural products better through genetic engineering. A part of that includes the Cannabis Industry and manufacturing ‘water-soluble CBD’. It will change the way people use many of the products they have today. This is a huge benefit for people who use CBD on a regular basis as well as the pharmaceutical industry. Both parties benefit from this technology and research.

    How This Works

    According to the research data, nano emulsions are water-in-oil or oil-in-water droplets blended in the right amounts. The molecules are broken down to the tiniest particles and then emulsified with a surfactant oil and water using ultrasonic technology. This process improves the oral bioavailability of lipophilic compounds like CBD and THC by making it water-soluble. If you can mix your CBD in coffee, tea, or other liquids and have it available instantly, that is the best way to deliver the benefits of CBD.

    Nano emulsion technology makes it possible to manufacture water-soluble CBD. With this new technology, the bioavailability of CBD increases remarkably with instant effects. 

    Check out our award winning Nano CBD products at 360 Organix CBD